The gut microbiome and autoimmunity: How our gut bacteria influence the immune system 🔬

Keywords:

Gut Microbiome, Autoimmunity, Lupus, Microbiome Research, Enterococcus gallinarum, Immunological Tolerance, Microbiome Therapies

Summary: 

In this episode of the Young Immunologist Podcast ImmunoChat, Pia Madeleine Leipe talks with Carina Brune about the role of the gut microbiome in the immune system and its connection to autoimmune diseases. They discuss the importance of gut microbes, the challenges in researching autoimmune diseases, and the potential therapeutic approaches emerging from microbiome research.

Takeaways:

• The gut microbiome plays a crucial role in regulating the immune system.
• Dysbiosis in the microbiome can lead to autoimmune diseases.
• Enterococcus gallinarum is a bacterium linked to the development of lupus.
• Future therapies may target microbiome modulation, including vaccines and phage therapy.

Please find here links to publications referred to in this Episode:  

General Info:

•  Family size, infection and atopy: the first decade of the 'hygiene hypothesis' | Thorax
• Host–microbiota interactions in immune-mediated diseases | Nature Reviews Microbiology

SLE and microbiome:

• Translocation of a gut pathobiont drives autoimmunity in mice and humans | Science
• Within-host evolution of a gut pathobiont facilitates liver translocation | Nature
• Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human | Science Translational Medicine
• Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders | Annals of the Rheumatic Diseases

 Phage therapy

• Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation: Cell

YouTube Video

Hinter den Kulissen des Tierlaboratoriums der Medizinischen Hochschule Hannover

Contact details

Carina Brune – University of Münster | LinkedIn

Immune-Microbiota Interactions Lab (@agkriegel.bsky.social) — Bluesky